An open repository of community-contributed protocols sponsored by Nature Research.
Learn more about Protocol Exchange
Method Article
Maria-Patapia Zafeiriou
UMG Göttingen
Corresponding Author
ORCiD: https://orcid.org/0000-0003-4604-4175
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Here we present a new directed differentiation and maturation protocol to generate Bioengineered Neuronal Organoids (BENOs) comprised of complex networks of inhibitory and excitatory neurons as well as supporting glial cells (astrocytes and myelinating oligodendrocytes).
Keywords
Neuronal organoid, stem cell, neuronal network formation, glial cell, oligodendrocyte, plasticity, GABA polarity switch, long-term potentiation
The University Medical Center Göttingen has filed a patent covering production and applications of the BENO technology (WO2018228948A1). M.P.Z. and W.H.Z are listed as inventors of the BENO technology. myriamed GmbH has licensed the BENO technology for applications in drug development. W.H.Z. is co-founder and equity holder of myriamed GmbH.
Loading...
Version History
CURRENT STATUS: Posted
Version 1
Posted 01 Aug, 2020
No community comments so far
Metrics
Comments: 0
HTML Views: ...
Associated Publications
Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids
by Maria-Patapia Zafeiriou, Guobin Bao, James Hudson, +6
Nature Communications (29 July, 2020)
An open repository of community-contributed protocols sponsored by Nature Research.
Learn more about Protocol Exchange
Method Article
Maria-Patapia Zafeiriou
UMG Göttingen
Corresponding Author
ORCiD: https://orcid.org/0000-0003-4604-4175
Version History
CURRENT STATUS: Posted
Version 1
Posted 01 Aug, 2020
No community comments so far
Metrics
Comments: 0
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Here we present a new directed differentiation and maturation protocol to generate Bioengineered Neuronal Organoids (BENOs) comprised of complex networks of inhibitory and excitatory neurons as well as supporting glial cells (astrocytes and myelinating oligodendrocytes).
The University Medical Center Göttingen has filed a patent covering production and applications of the BENO technology (WO2018228948A1). M.P.Z. and W.H.Z are listed as inventors of the BENO technology. myriamed GmbH has licensed the BENO technology for applications in drug development. W.H.Z. is co-founder and equity holder of myriamed GmbH.
Loading...
Associated Publications
Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids
by Maria-Patapia Zafeiriou, Guobin Bao, James Hudson, +6
Nature Communications (29 July, 2020)