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Method Article
Xinyue Yuan
ETH Zurich
Corresponding Author
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The use of high-density microelectrode arrays (HD-MEAs) provides a promising approach for electrophysiological studies targeted at understanding of brain functions, profiling of neurodegenerative diseases, and drug screening. Here we present the protocol for the preparation of various biological samples for the recording of extracellular signals using HD-MEA, including primary cortical neurons, induced pluripotent stem cells (iPSCs)-derived neurons, rodent brain slices, retina, and iPSC-derived neuronal spheroids.
Keywords
Electrophysiology, high-density microelectrode arrays, extracellular recording
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Posted 28 Sep, 2020
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Neuroscience
Associated Publications
Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level
by Xinyue Yuan, Manuel Schröter, Marie Engelene J. Obien, +9
Nature Communications (25 September, 2020)
An open repository of community-contributed protocols sponsored by Nature Research.
Learn more about Protocol Exchange
Method Article
Xinyue Yuan
ETH Zurich
Corresponding Author
Version History
CURRENT STATUS: Posted
Version 1
Posted 28 Sep, 2020
Community comments: 1
Metrics
Comments: 0
HTML Views: ...
Subject Areas
Neuroscience
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The use of high-density microelectrode arrays (HD-MEAs) provides a promising approach for electrophysiological studies targeted at understanding of brain functions, profiling of neurodegenerative diseases, and drug screening. Here we present the protocol for the preparation of various biological samples for the recording of extracellular signals using HD-MEA, including primary cortical neurons, induced pluripotent stem cells (iPSCs)-derived neurons, rodent brain slices, retina, and iPSC-derived neuronal spheroids.
Loading...
Associated Publications
Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level
by Xinyue Yuan, Manuel Schröter, Marie Engelene J. Obien, +9
Nature Communications (25 September, 2020)