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Method Article
Preparation of biological samples for the recording of electrophysiological signals using high-density microelectrode arrays
Xinyue Yuan
ETH Zurich
Corresponding Author
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The use of high-density microelectrode arrays (HD-MEAs) provides a promising approach for electrophysiological studies targeted at understanding of brain functions, profiling of neurodegenerative diseases, and drug screening. Here we present the protocol for the preparation of various biological samples for the recording of extracellular signals using HD-MEA, including primary cortical neurons, induced pluripotent stem cells (iPSCs)-derived neurons, rodent brain slices, retina, and iPSC-derived neuronal spheroids.
Keywords
Electrophysiology, high-density microelectrode arrays, extracellular recording
Salman Raza
commented on 29 September, 2020
Wonderful Prof Salman Raza Principal Government Degree Boys College 5L New Karachi Pakistan College Education Department Government of Sindh Province Pakistan Prof of Zoology World Renowned Zoologist and Entomologist
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Associated Publications
Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level
by Xinyue Yuan, Manuel Schröter, Marie Engelene J. Obien, +9
Nature Communications (25 September, 2020)
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This is a preprint. It has not completed peer review.
Method Article
Preparation of biological samples for the recording of electrophysiological signals using high-density microelectrode arrays
Xinyue Yuan
ETH Zurich
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 28 Sep, 2020
Community comments: 1
Metrics
Comments: 1
HTML Views: ...
Subject Areas
Neuroscience
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The use of high-density microelectrode arrays (HD-MEAs) provides a promising approach for electrophysiological studies targeted at understanding of brain functions, profiling of neurodegenerative diseases, and drug screening. Here we present the protocol for the preparation of various biological samples for the recording of extracellular signals using HD-MEA, including primary cortical neurons, induced pluripotent stem cells (iPSCs)-derived neurons, rodent brain slices, retina, and iPSC-derived neuronal spheroids.
Salman Raza
commented on 29 September, 2020
Wonderful Prof Salman Raza Principal Government Degree Boys College 5L New Karachi Pakistan College Education Department Government of Sindh Province Pakistan Prof of Zoology World Renowned Zoologist and Entomologist
Associated Publications
Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level
by Xinyue Yuan, Manuel Schröter, Marie Engelene J. Obien, +9
Nature Communications (25 September, 2020)