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Method Article
In vitro antimicrobial assay of nano-iron sulfide (nFeS)
Lizeng Gao
Gao Lab (Yangzhou University)
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
This protocol describes a detailed process of antibacterial (Streptococcus mutans UA159) activity by nanometer-sized iron sulfide (nFeS). Streptococcus mutans has long been considered to be a critical factor in caries-causing plaque development. The pathogens are enriched in 3D matrix of extracellular polymeric substances and lead to dental caries by producing highly acidic niches. We find that nano-iron sulfide improves the killing efficacy of Streptococcus mutans UA159 by more than 500 times compaired with garlic-derived organosulfur compounds. Here the Fe3O4 nanoparticles and nFeS( Cys-nFeS, GSH-nFeS, NaHS-nFeS, Cyss-nFeS, and DADS-nFeS ) converted from different organosulfur sources were used to evaluate the antimicrobial (Streptococcus mutans UA159) activity within 30 minutes.
Keywords
pathogens; Streptococcus mutans UA159; bactericidal; dental caries
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Associated Publications
Converting organosulfur compounds to inorganic polysulfides against resistant bacterial infections
by Zhuobin Xu, Zhiyue Qiu, Qi Liu, +15
Nature Communications (22 November, 2018)
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This is a preprint. It has not completed peer review.
Method Article
In vitro antimicrobial assay of nano-iron sulfide (nFeS)
Lizeng Gao
Gao Lab (Yangzhou University)
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 03 Dec, 2018
No community comments so far
Metrics
Comments: 0
HTML Views: ...
Subject Areas
Microbiology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
This protocol describes a detailed process of antibacterial (Streptococcus mutans UA159) activity by nanometer-sized iron sulfide (nFeS). Streptococcus mutans has long been considered to be a critical factor in caries-causing plaque development. The pathogens are enriched in 3D matrix of extracellular polymeric substances and lead to dental caries by producing highly acidic niches. We find that nano-iron sulfide improves the killing efficacy of Streptococcus mutans UA159 by more than 500 times compaired with garlic-derived organosulfur compounds. Here the Fe3O4 nanoparticles and nFeS( Cys-nFeS, GSH-nFeS, NaHS-nFeS, Cyss-nFeS, and DADS-nFeS ) converted from different organosulfur sources were used to evaluate the antimicrobial (Streptococcus mutans UA159) activity within 30 minutes.
Figure 1
Associated Publications
Converting organosulfur compounds to inorganic polysulfides against resistant bacterial infections
by Zhuobin Xu, Zhiyue Qiu, Qi Liu, +15
Nature Communications (22 November, 2018)