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Method Article
Lizeng Gao
Gao Lab (Yangzhou University)
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
This protocol describes a detailed process of antibacterial (Streptococcus mutans UA159) activity by nanometer-sized iron sulfide (nFeS). Streptococcus mutans has long been considered to be a critical factor in caries-causing plaque development. The pathogens are enriched in 3D matrix of extracellular polymeric substances and lead to dental caries by producing highly acidic niches. We find that nano-iron sulfide improves the killing efficacy of Streptococcus mutans UA159 by more than 500 times compaired with garlic-derived organosulfur compounds. Here the Fe3O4 nanoparticles and nFeS( Cys-nFeS, GSH-nFeS, NaHS-nFeS, Cyss-nFeS, and DADS-nFeS ) converted from different organosulfur sources were used to evaluate the antimicrobial (Streptococcus mutans UA159) activity within 30 minutes.
Keywords
pathogens; Streptococcus mutans UA159; bactericidal; dental caries
Figure 1
The authors declare no conflicting financial interests.
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Microbiology
Associated Publications
Converting organosulfur compounds to inorganic polysulfides against resistant bacterial infections
by Zhuobin Xu, Zhiyue Qiu, Qi Liu, +15
Nature Communications (22 November, 2018)
An open repository of community-contributed protocols sponsored by Nature Research.
Learn more about Protocol Exchange
Method Article
Lizeng Gao
Gao Lab (Yangzhou University)
Corresponding Author
Version History
CURRENT STATUS: Posted
Version 1
Posted 03 Dec, 2018
No community comments so far
Metrics
Comments: 0
HTML Views: ...
Subject Areas
Microbiology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
This protocol describes a detailed process of antibacterial (Streptococcus mutans UA159) activity by nanometer-sized iron sulfide (nFeS). Streptococcus mutans has long been considered to be a critical factor in caries-causing plaque development. The pathogens are enriched in 3D matrix of extracellular polymeric substances and lead to dental caries by producing highly acidic niches. We find that nano-iron sulfide improves the killing efficacy of Streptococcus mutans UA159 by more than 500 times compaired with garlic-derived organosulfur compounds. Here the Fe3O4 nanoparticles and nFeS( Cys-nFeS, GSH-nFeS, NaHS-nFeS, Cyss-nFeS, and DADS-nFeS ) converted from different organosulfur sources were used to evaluate the antimicrobial (Streptococcus mutans UA159) activity within 30 minutes.
Figure 1
The authors declare no conflicting financial interests.
Loading...
Associated Publications
Converting organosulfur compounds to inorganic polysulfides against resistant bacterial infections
by Zhuobin Xu, Zhiyue Qiu, Qi Liu, +15
Nature Communications (22 November, 2018)