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Method Article
Anne-Katrien Stark
Division of Immunology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK
Corresponding Author
Klaus Okkenhaug
Division of Immunology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Streptococcus pneumoniae is a globally important pathogen. We describe a mouse model of S. pneumoniae respiratory tract infection through intranasal administration of bacteria which progress to bacteraemia and systemic disease. This model therefore allows assessment of different stages of infection and can be used to study local and systemic immune responses to vaccines and other treatment strategies.
Keywords
Intranasal infection, Mouse model, Streptococcus pneumoniae, Flow cytometry
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The authors declare no competing financial interests
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Biological techniques
Associated Publications
PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner
by Anne-Katrien Stark, Anita Chandra, Krishnendu Chakraborty, +11
Nature Communications (19 September, 2018)
An open repository of community-contributed protocols sponsored by Nature Research.
Learn more about Protocol Exchange
Method Article
Anne-Katrien Stark
Division of Immunology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK
Corresponding Author
Klaus Okkenhaug
Division of Immunology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK
Corresponding Author
Version History
CURRENT STATUS: Posted
Version 1
Posted 24 Sep, 2018
No community comments so far
Metrics
Comments: 0
HTML Views: ...
Subject Areas
Biological techniques
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Streptococcus pneumoniae is a globally important pathogen. We describe a mouse model of S. pneumoniae respiratory tract infection through intranasal administration of bacteria which progress to bacteraemia and systemic disease. This model therefore allows assessment of different stages of infection and can be used to study local and systemic immune responses to vaccines and other treatment strategies.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
The authors declare no competing financial interests
Loading...
Associated Publications
PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner
by Anne-Katrien Stark, Anita Chandra, Krishnendu Chakraborty, +11
Nature Communications (19 September, 2018)