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Method Article
Acute Streptococcus pneumoniae lung infection: Mouse model and characterisation of the immune response.
Anne-Katrien Stark
Division of Immunology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK
Corresponding Author
Klaus Okkenhaug
Division of Immunology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Streptococcus pneumoniae is a globally important pathogen. We describe a mouse model of S. pneumoniae respiratory tract infection through intranasal administration of bacteria which progress to bacteraemia and systemic disease. This model therefore allows assessment of different stages of infection and can be used to study local and systemic immune responses to vaccines and other treatment strategies.
Keywords
Intranasal infection, Mouse model, Streptococcus pneumoniae, Flow cytometry
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Associated Publications
PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner
by Anne-Katrien Stark, Anita Chandra, Krishnendu Chakraborty, +11
Nature Communications (19 September, 2018)
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This is a preprint. It has not completed peer review.
Method Article
Acute Streptococcus pneumoniae lung infection: Mouse model and characterisation of the immune response.
Anne-Katrien Stark
Division of Immunology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK
Corresponding Author
Klaus Okkenhaug
Division of Immunology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 24 Sep, 2018
No community comments so far
Metrics
Comments: 0
HTML Views: ...
Subject Areas
Biological techniques
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Streptococcus pneumoniae is a globally important pathogen. We describe a mouse model of S. pneumoniae respiratory tract infection through intranasal administration of bacteria which progress to bacteraemia and systemic disease. This model therefore allows assessment of different stages of infection and can be used to study local and systemic immune responses to vaccines and other treatment strategies.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
Associated Publications
PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner
by Anne-Katrien Stark, Anita Chandra, Krishnendu Chakraborty, +11
Nature Communications (19 September, 2018)