Creating a screening set of potential anthelmintic compounds using ChEMBL
Many existing anthelmintic compounds are compromised by low efficacy, serious side-effects and/or rising resistance in parasite populations. Thus, to reveal potential new drug targets and drugs, we describe a protocol to identify the most promising nematode/flatworm targets, and compounds likely to interact with them from the ChEMBL database (which includes both targets of known drugs and of other biologically active compounds). This provides a potential screening set of drug-like compounds.
Figure 1
Posted 14 May, 2018
Creating a screening set of potential anthelmintic compounds using ChEMBL
Posted 14 May, 2018
Many existing anthelmintic compounds are compromised by low efficacy, serious side-effects and/or rising resistance in parasite populations. Thus, to reveal potential new drug targets and drugs, we describe a protocol to identify the most promising nematode/flatworm targets, and compounds likely to interact with them from the ChEMBL database (which includes both targets of known drugs and of other biologically active compounds). This provides a potential screening set of drug-like compounds.
Figure 1
© Research Square 2021