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Method Article
Creating a screening set of potential anthelmintic compounds using ChEMBL
Matthew Berriman
Berriman Lab Group, Sanger Institute
Corresponding Author
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Many existing anthelmintic compounds are compromised by low efficacy, serious side-effects and/or rising resistance in parasite populations. Thus, to reveal potential new drug targets and drugs, we describe a protocol to identify the most promising nematode/flatworm targets, and compounds likely to interact with them from the ChEMBL database (which includes both targets of known drugs and of other biologically active compounds). This provides a potential screening set of drug-like compounds.
Keywords
drug discovery, drugs, anthemintic, helminths, nematodes, flatworms, parasites, parasitic worms, platyhelminths, Nematoda, Platyhelminthes, compounds, anthelminthic, ChEMBL
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This is a preprint. It has not completed peer review.
Method Article
Creating a screening set of potential anthelmintic compounds using ChEMBL
Matthew Berriman
Berriman Lab Group, Sanger Institute
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 14 May, 2018
No community comments so far
Metrics
Comments: 0
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Many existing anthelmintic compounds are compromised by low efficacy, serious side-effects and/or rising resistance in parasite populations. Thus, to reveal potential new drug targets and drugs, we describe a protocol to identify the most promising nematode/flatworm targets, and compounds likely to interact with them from the ChEMBL database (which includes both targets of known drugs and of other biologically active compounds). This provides a potential screening set of drug-like compounds.
Figure 1