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Method Article
A multicentre randomised controlled trial to compare the efficacy of ex-vivo normothermic machine perfusion with static cold storage in human liver transplantation
David Nasralla
Consortium for Organ Preservation in Europe and Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK
Corresponding Author
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The global organ shortage has necessitated the use of increasingly marginal livers for transplantation. The current standard method of liver preservation, static cold storage (SCS), is not suitable for many marginal organs, increasing the risk of significant complications or graft failure. Normothermic machine perfusion (NMP) enables the liver to be preserved in a functioning physiological state. Previous animal studies suggest this may improve the quality of organs after transplantation. This protocol relates to the first multi-national, randomised controlled clinical trial to directly compare SCS with NMP in human liver transplantation.
Keywords
clinical trial; liver transplantation; organ preservation; normothermic perfusion
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NMP vs SCS Clinical Trial Protocol A multicentre randomised controlled trial to compare the efficacy of ex-vivo normothermic machine perfusion with static cold storage in human liver transplantation
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This is a preprint. It has not completed peer review.
Method Article
A multicentre randomised controlled trial to compare the efficacy of ex-vivo normothermic machine perfusion with static cold storage in human liver transplantation
David Nasralla
Consortium for Organ Preservation in Europe and Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 14 May, 2018
No community comments so far
Metrics
Comments: 0
HTML Views: ...
Subject Areas
Biological techniques
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The global organ shortage has necessitated the use of increasingly marginal livers for transplantation. The current standard method of liver preservation, static cold storage (SCS), is not suitable for many marginal organs, increasing the risk of significant complications or graft failure. Normothermic machine perfusion (NMP) enables the liver to be preserved in a functioning physiological state. Previous animal studies suggest this may improve the quality of organs after transplantation. This protocol relates to the first multi-national, randomised controlled clinical trial to directly compare SCS with NMP in human liver transplantation.