This is a protocol preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Method Article
David Nasralla
Consortium for Organ Preservation in Europe and Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The global organ shortage has necessitated the use of increasingly marginal livers for transplantation. The current standard method of liver preservation, static cold storage (SCS), is not suitable for many marginal organs, increasing the risk of significant complications or graft failure. Normothermic machine perfusion (NMP) enables the liver to be preserved in a functioning physiological state. Previous animal studies suggest this may improve the quality of organs after transplantation. This protocol relates to the first multi-national, randomised controlled clinical trial to directly compare SCS with NMP in human liver transplantation.
Keywords
clinical trial; liver transplantation; organ preservation; normothermic perfusion
Professor Peter Friend is a co-founder, Chief Medical Officer and Consultant to OrganOx Limited and also holds shares in the company.
This is a list of supplementary files associated with this preprint. Click to download.
- supplement0.pdf
NMP vs SCS Clinical Trial Protocol A multicentre randomised controlled trial to compare the efficacy of ex-vivo normothermic machine perfusion with static cold storage in human liver transplantation
Loading...
Version History
CURRENT STATUS: Posted
Version 1
Posted 14 May, 2018
No community comments so far
Metrics
Comments: 0
HTML Views: ...
Subject Areas
Biological techniques
Method Article
David Nasralla
Consortium for Organ Preservation in Europe and Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK
Corresponding Author
Version History
CURRENT STATUS: Posted
Version 1
Posted 14 May, 2018
No community comments so far
Metrics
Comments: 0
HTML Views: ...
Subject Areas
Biological techniques
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The global organ shortage has necessitated the use of increasingly marginal livers for transplantation. The current standard method of liver preservation, static cold storage (SCS), is not suitable for many marginal organs, increasing the risk of significant complications or graft failure. Normothermic machine perfusion (NMP) enables the liver to be preserved in a functioning physiological state. Previous animal studies suggest this may improve the quality of organs after transplantation. This protocol relates to the first multi-national, randomised controlled clinical trial to directly compare SCS with NMP in human liver transplantation.
Loading...