Synthesis of nNOS-Capon interaction inhibitors: ZLc-002 and its derivatives
nNOS-Capon interaction is involved in anxiety disorder, disrupting the nNOS-Capon interaction has been demonstrated to show anxiolytic-like effect. In this protocol, N-(2-carbomethoxyacetyl)-D-valine methyl ester, a nNOS-Capon interaction inhibitor, we named it ZLc-002, was prepared by condensation of D-valine methyl ester hydrochloride with methyl malonyl chloride. The synthesis of some analogues of ZLc-002 was also described.
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This is associated with a Nature Medicine paper:CAPON-nNOS coupling can serve as a target for developing new anxiolytics 10.1038/nm.3644 http://www.nature.com/nm/journal/v20/n9/full/nm.3644.html
This is associated with a Nature Medicine paper:CAPON-nNOS coupling can serve as a target for developing new anxiolytics 10.1038/nm.3644 http://www.nature.com/nm/journal/v20/n9/full/nm.3644.html
Posted 16 Sep, 2014
Synthesis of nNOS-Capon interaction inhibitors: ZLc-002 and its derivatives
Posted 16 Sep, 2014
nNOS-Capon interaction is involved in anxiety disorder, disrupting the nNOS-Capon interaction has been demonstrated to show anxiolytic-like effect. In this protocol, N-(2-carbomethoxyacetyl)-D-valine methyl ester, a nNOS-Capon interaction inhibitor, we named it ZLc-002, was prepared by condensation of D-valine methyl ester hydrochloride with methyl malonyl chloride. The synthesis of some analogues of ZLc-002 was also described.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
This is associated with a Nature Medicine paper:CAPON-nNOS coupling can serve as a target for developing new anxiolytics 10.1038/nm.3644 http://www.nature.com/nm/journal/v20/n9/full/nm.3644.html
This is associated with a Nature Medicine paper:CAPON-nNOS coupling can serve as a target for developing new anxiolytics 10.1038/nm.3644 http://www.nature.com/nm/journal/v20/n9/full/nm.3644.html
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