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Method Article
Synthesis of nNOS-Capon interaction inhibitors: ZLc-002 and its derivatives
Dong-Ya Zhu
Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China
Corresponding Author
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nNOS-Capon interaction is involved in anxiety disorder, disrupting the nNOS-Capon interaction has been demonstrated to show anxiolytic-like effect. In this protocol, N-(2-carbomethoxyacetyl)-D-valine methyl ester, a nNOS-Capon interaction inhibitor, we named it ZLc-002, was prepared by condensation of D-valine methyl ester hydrochloride with methyl malonyl chloride. The synthesis of some analogues of ZLc-002 was also described.
Keywords
Anxiety, Anxiolytic, ZLc-002, nNOS, Capon
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commented on 15 September, 2014
This is associated with a Nature Medicine paper:CAPON-nNOS coupling can serve as a target for developing new anxiolytics 10.1038/nm.3644 http://www.nature.com/nm/journal/v20/n9/full/nm.3644.html
commented on 15 September, 2014
This is associated with a Nature Medicine paper:CAPON-nNOS coupling can serve as a target for developing new anxiolytics 10.1038/nm.3644 http://www.nature.com/nm/journal/v20/n9/full/nm.3644.html
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Synthetic chemistry
Associated Publications
CAPON-nNOS coupling can serve as a target for developing new anxiolytics
by Li-Juan Zhu, Ting-You Li, Chun-Xia Luo, +15
Nature Medicine (04 September, 2014)
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This is a preprint. It has not completed peer review.
Method Article
Synthesis of nNOS-Capon interaction inhibitors: ZLc-002 and its derivatives
Dong-Ya Zhu
Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 16 Sep, 2014
Community comments: 2
Metrics
Comments: 2
HTML Views: ...
Subject Areas
Synthetic chemistry
License:
This work is licensed under a CC BY-NC 3.0 License. Read Full License
nNOS-Capon interaction is involved in anxiety disorder, disrupting the nNOS-Capon interaction has been demonstrated to show anxiolytic-like effect. In this protocol, N-(2-carbomethoxyacetyl)-D-valine methyl ester, a nNOS-Capon interaction inhibitor, we named it ZLc-002, was prepared by condensation of D-valine methyl ester hydrochloride with methyl malonyl chloride. The synthesis of some analogues of ZLc-002 was also described.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
commented on 15 September, 2014
This is associated with a Nature Medicine paper:CAPON-nNOS coupling can serve as a target for developing new anxiolytics 10.1038/nm.3644 http://www.nature.com/nm/journal/v20/n9/full/nm.3644.html
commented on 15 September, 2014
This is associated with a Nature Medicine paper:CAPON-nNOS coupling can serve as a target for developing new anxiolytics 10.1038/nm.3644 http://www.nature.com/nm/journal/v20/n9/full/nm.3644.html
Associated Publications
CAPON-nNOS coupling can serve as a target for developing new anxiolytics
by Li-Juan Zhu, Ting-You Li, Chun-Xia Luo, +15
Nature Medicine (04 September, 2014)