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Method Article
Dong-Ya Zhu
Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China
Corresponding Author
License:
This work is licensed under a CC BY-NC 3.0 License. Read Full License
nNOS-Capon interaction is involved in anxiety disorder, disrupting the nNOS-Capon interaction has been demonstrated to show anxiolytic-like effect. In this protocol, N-(2-carbomethoxyacetyl)-D-valine methyl ester, a nNOS-Capon interaction inhibitor, we named it ZLc-002, was prepared by condensation of D-valine methyl ester hydrochloride with methyl malonyl chloride. The synthesis of some analogues of ZLc-002 was also described.
Keywords
Anxiety, Anxiolytic, ZLc-002, nNOS, Capon
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The authors declare no competing financial interests.
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CURRENT STATUS: Posted
Version 1
Posted 16 Sep, 2014
Community comments: 2
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Subject Areas
Synthetic chemistry
Associated Publications
CAPON-nNOS coupling can serve as a target for developing new anxiolytics
by Li-Juan Zhu, Ting-You Li, Chun-Xia Luo, +15
Nature Medicine (04 September, 2014)
An open repository of community-contributed protocols sponsored by Nature Research.
Learn more about Protocol Exchange
Method Article
Dong-Ya Zhu
Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China
Corresponding Author
Version History
CURRENT STATUS: Posted
Version 1
Posted 16 Sep, 2014
Community comments: 2
Metrics
Comments: 0
HTML Views: ...
Subject Areas
Synthetic chemistry
License:
This work is licensed under a CC BY-NC 3.0 License. Read Full License
nNOS-Capon interaction is involved in anxiety disorder, disrupting the nNOS-Capon interaction has been demonstrated to show anxiolytic-like effect. In this protocol, N-(2-carbomethoxyacetyl)-D-valine methyl ester, a nNOS-Capon interaction inhibitor, we named it ZLc-002, was prepared by condensation of D-valine methyl ester hydrochloride with methyl malonyl chloride. The synthesis of some analogues of ZLc-002 was also described.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9
The authors declare no competing financial interests.
Loading...
Associated Publications
CAPON-nNOS coupling can serve as a target for developing new anxiolytics
by Li-Juan Zhu, Ting-You Li, Chun-Xia Luo, +15
Nature Medicine (04 September, 2014)