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Method Article
Xuemei Wang
State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China
Corresponding Author
License:
This work is licensed under a CC BY-NC 3.0 License. Read Full License
The unique optical properties of biocompatible metal nanoclusters have attracted much attention in bio-imaging and bioanalysis. In this contribution, the protocols of the design of gold nanoclusters (GNCs) and their nanocomposites for cancer cell imaging and tumor target bio-marking in small animal models have been demonstrated. The gold nanoclusters impregnated on the reduced graphene oxide nanosheets allow a clear fluorescence imaging of the edges and morphology of the cells. The specific and sensitive self-bio-marking of cancer cells and tumors is also achieved through in situ biosynthesized fluorescent GNCs, which are spontaneously and selectively biosynthesized by cancerous cells or tumor sites / microenvironments when incubated with a biocompatible molecular Au(III) species. These procedures take various times ranging from 0.5 h to 3 d.
Keywords
gold nanoclusters; cell imaging; tumor bio-marking
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The authors declare no competing financial interests.
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Associated Publications
In vivo self-bio-imaging of tumors through in situ biosynthesized fluorescent gold nanoclusters
by Jianling Wang, Gen Zhang, Qiwei Li, +4
Scientific Reports (28 February, 2014)
Gold Nanoclusters and Graphene Nanocomposites for Drug Delivery and Imaging of Cancer Cells
by Chensu Wang, Jingyuan Li, Christian Amatore, +3
Angewandte Chemie International Edition (28 February, 2014)
An open repository of community-contributed protocols sponsored by Nature Research.
Learn more about Protocol Exchange
Method Article
Xuemei Wang
State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China
Corresponding Author
Version History
CURRENT STATUS: Posted
Version 1
Posted 28 Feb, 2014
No community comments so far
Metrics
Comments: 0
HTML Views: ...
License:
This work is licensed under a CC BY-NC 3.0 License. Read Full License
The unique optical properties of biocompatible metal nanoclusters have attracted much attention in bio-imaging and bioanalysis. In this contribution, the protocols of the design of gold nanoclusters (GNCs) and their nanocomposites for cancer cell imaging and tumor target bio-marking in small animal models have been demonstrated. The gold nanoclusters impregnated on the reduced graphene oxide nanosheets allow a clear fluorescence imaging of the edges and morphology of the cells. The specific and sensitive self-bio-marking of cancer cells and tumors is also achieved through in situ biosynthesized fluorescent GNCs, which are spontaneously and selectively biosynthesized by cancerous cells or tumor sites / microenvironments when incubated with a biocompatible molecular Au(III) species. These procedures take various times ranging from 0.5 h to 3 d.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
The authors declare no competing financial interests.
Loading...
Associated Publications
In vivo self-bio-imaging of tumors through in situ biosynthesized fluorescent gold nanoclusters
by Jianling Wang, Gen Zhang, Qiwei Li, +4
Scientific Reports (28 February, 2014)
Gold Nanoclusters and Graphene Nanocomposites for Drug Delivery and Imaging of Cancer Cells
by Chensu Wang, Jingyuan Li, Christian Amatore, +3
Angewandte Chemie International Edition (28 February, 2014)