The purpose of this epidemiological study was to investigate the long-term effects of exposure to aircraft noise on reading comprehension on a sample of South African children. Given the impairment of reading comprehension found within the noised-exposed group before the relocation of the airport, it was the intention of this study to determine whether the effects of aircraft noise on reading comprehension remained after the relocation of the airport or whether they disappeared. A cohort of 732 learners with a mean age of 11.1 participated at baseline measurements in 2009 and 650 (mean age = 12.3) and 178 (mean age = 13.1) learners were reassessed after the relocation of the airport in 2010 and 2011, respectively. The results revealed no significant effect of the groups on reading comprehension across the testing periods, but significant effects of home language were demonstrated on reading comprehension. These findings suggest that exposure to chronic aircraft noise may have a lasting impact on children’s reading comprehension functioning.