Autism-related behavioral deficits in rodents are most often studied with regard to impairment in reciprocal social interaction. The social interaction test is a simple test in which behaviors are video-recorded and analyzed to assess active interaction time in a test mouse with a novel mouse. Using this test, we found a reduction of social interaction in mouse models of tuberous sclerosis complex, in which the mice exhibited normal approach to a novel conspecific in three-chamber social approach task. These results suggest that the social interaction test is more sensitive than the three-chamber social approach task for detecting social deficits. Moreover, other behaviors can be measured by analyzing the recorded video, such as rearing behavior, which was increased in mouse models of tuberous sclerosis complex.