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Method Article
Mass Spectrometry Imaging of Invisible Micro-Patterns on Graphene Substrate
Chengzhong Yu
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia
Corresponding Author
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Invisible micro-patterns of trace amount molecules can be recognized through the mass spectrometry (MS) imaging technique on the engineered graphene film without additional chemicals such as organic matrix. The micro-patterns can be prepared in a controlled manner, where simple stamping was employed and diluted solution of molecules was used as the invisible ink. It is noted that due to the low concentration (pmol/µL) and detection of limit (fmol) for detection and imaging achieved in this protocol, the engineered graphene paper can be applied in not only tissue blotting for small metabolites and lipids molecules, but also forensic study to track trace amount of chemicals (such as drugs) in the latent fingerprint and record/monitor the invisible micro-pattern of specific molecules.
Keywords
Mass Spectrometry, Imaging, Micro-patterns
Figure 1
Sciker Nature
commented on 29 September, 2013
I am interested in this writing on Graphene Substrate. Can I get this full article as a PDF? Thanks
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commented on 08 October, 2013
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Sciker Nature
commented on 29 September, 2013
I am interested in this writing on Graphene Substrate. Can I get this full article as a PDF? Thanks
Christopher Surridge
commented on 08 October, 2013
Dear Sciker,Thank you for your comment on the Protocol Exchange article. We do not explicitly create PDFs of Protocol Exchange pieces, however if you wish for the article in that form you can use the 'Print' function on the article and adjust the settings to save the file as a PDF rather than outputting to a physical printer.Christopher Surridge Chief Editor, Nature Protocols
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Associated Publications
Laser Engineered Graphene Paper for Mass Spectrometry Imaging
by Kun Qian, Liang Zhou, Jian Liu, +7
Scientific Reports (28 February, 2013)
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This is a preprint. It has not completed peer review.
Method Article
Mass Spectrometry Imaging of Invisible Micro-Patterns on Graphene Substrate
Chengzhong Yu
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 12 Mar, 2013
Community comments: 4
Metrics
Comments: 4
HTML Views: ...
License:
This work is licensed under a CC BY-NC 3.0 License. Read Full License
Invisible micro-patterns of trace amount molecules can be recognized through the mass spectrometry (MS) imaging technique on the engineered graphene film without additional chemicals such as organic matrix. The micro-patterns can be prepared in a controlled manner, where simple stamping was employed and diluted solution of molecules was used as the invisible ink. It is noted that due to the low concentration (pmol/µL) and detection of limit (fmol) for detection and imaging achieved in this protocol, the engineered graphene paper can be applied in not only tissue blotting for small metabolites and lipids molecules, but also forensic study to track trace amount of chemicals (such as drugs) in the latent fingerprint and record/monitor the invisible micro-pattern of specific molecules.
Figure 1
Sciker Nature
commented on 29 September, 2013
I am interested in this writing on Graphene Substrate. Can I get this full article as a PDF? Thanks
Christopher Surridge
commented on 08 October, 2013
Dear Sciker,Thank you for your comment on the Protocol Exchange article. We do not explicitly create PDFs of Protocol Exchange pieces, however if you wish for the article in that form you can use the 'Print' function on the article and adjust the settings to save the file as a PDF rather than outputting to a physical printer.Christopher Surridge Chief Editor, Nature Protocols
Sciker Nature
commented on 29 September, 2013
I am interested in this writing on Graphene Substrate. Can I get this full article as a PDF? Thanks
Christopher Surridge
commented on 08 October, 2013
Dear Sciker,Thank you for your comment on the Protocol Exchange article. We do not explicitly create PDFs of Protocol Exchange pieces, however if you wish for the article in that form you can use the 'Print' function on the article and adjust the settings to save the file as a PDF rather than outputting to a physical printer.Christopher Surridge Chief Editor, Nature Protocols
2 comments flagged for moderation
If you posted a comment and think it was mistakenly removed, please contact customer support at [email protected].
Associated Publications
Laser Engineered Graphene Paper for Mass Spectrometry Imaging
by Kun Qian, Liang Zhou, Jian Liu, +7
Scientific Reports (28 February, 2013)