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Method Article
Chengzhong Yu
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia
Corresponding Author
License:
This work is licensed under a CC BY-NC 3.0 License. Read Full License
Invisible micro-patterns of trace amount molecules can be recognized through the mass spectrometry (MS) imaging technique on the engineered graphene film without additional chemicals such as organic matrix. The micro-patterns can be prepared in a controlled manner, where simple stamping was employed and diluted solution of molecules was used as the invisible ink. It is noted that due to the low concentration (pmol/µL) and detection of limit (fmol) for detection and imaging achieved in this protocol, the engineered graphene paper can be applied in not only tissue blotting for small metabolites and lipids molecules, but also forensic study to track trace amount of chemicals (such as drugs) in the latent fingerprint and record/monitor the invisible micro-pattern of specific molecules.
Keywords
Mass Spectrometry, Imaging, Micro-patterns
Figure 1
The authors declare no competing financial interests.
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Associated Publications
Laser Engineered Graphene Paper for Mass Spectrometry Imaging
by Kun Qian, Liang Zhou, Jian Liu, +7
Scientific Reports (28 February, 2013)
An open repository of community-contributed protocols sponsored by Nature Research.
Learn more about Protocol Exchange
Method Article
Chengzhong Yu
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia
Corresponding Author
Version History
CURRENT STATUS: Posted
Version 1
Posted 12 Mar, 2013
Community comments: 4
Metrics
Comments: 0
HTML Views: ...
License:
This work is licensed under a CC BY-NC 3.0 License. Read Full License
Invisible micro-patterns of trace amount molecules can be recognized through the mass spectrometry (MS) imaging technique on the engineered graphene film without additional chemicals such as organic matrix. The micro-patterns can be prepared in a controlled manner, where simple stamping was employed and diluted solution of molecules was used as the invisible ink. It is noted that due to the low concentration (pmol/µL) and detection of limit (fmol) for detection and imaging achieved in this protocol, the engineered graphene paper can be applied in not only tissue blotting for small metabolites and lipids molecules, but also forensic study to track trace amount of chemicals (such as drugs) in the latent fingerprint and record/monitor the invisible micro-pattern of specific molecules.
Figure 1
The authors declare no competing financial interests.
Loading...
Associated Publications
Laser Engineered Graphene Paper for Mass Spectrometry Imaging
by Kun Qian, Liang Zhou, Jian Liu, +7
Scientific Reports (28 February, 2013)