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Method Article
Enhancing graphene/CNT based electrochemical detection using magneto-nanobioprobes
C. Raman Suri
IMTECH
Corresponding Author
License:
This work is licensed under a CC BY-NC 3.0 License. Read Full License
This protocol describes an optimized signal amplification strategy to develop an ultra-sensitive magneto-electrochemical biosensing platform. The new protocol combines the advantages of carbon nanotube (CNT) and reduced graphene oxide (rGO) together with electrochemical bursting of magnetic nanoparticles. The method involves synthesis of gold-iron (Au/Fe) nano-structures functionalized with specific antibodies to be used as nanobioprobes (Ab-Au/Fe). The next step requires the precise designing of the rGO/CNT nanohybrid sensing platform. The combined system offers the enhanced electrochemical properties giving a synergistic effect in electroanalytical performance of the resulting electrode material along with a large number of metal ions (Fe2+) available on electrode demonstrating ultra-high sensitivity of developed assay. This method provides a promising biosensing platform for environmental or clinical applications where sensitivity is a major issue
Keywords
Nanocomposites, nanobioprobes, metal ions, diuron
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gunmala sur
commented on 08 December, 2012
The protocol looks very exciting for sensitive detection of analytes, and could be an alternate for existing techniques
gunmala sur
commented on 08 December, 2012
thanks
gunmala sur
commented on 09 December, 2012
Very exciting protocol for sensitive detection of analytes. I need more details on the electrode characterization part of this method.
suresh aryan
commented on 28 December, 2012
A simple, efficient and innovative approach for biosensing, using new generation smart nanoscale materials (graphene, CNTs and Fe/Au nanocrystals) has been presented. The technique may be useful for development of new highly efficient biosensors. Definitely an impressive piece of work.
suresh aryan
commented on 28 December, 2012
A simple, efficient and innovative approach for biosensing, using new generation smart nanoscale materials (graphene, CNTs and Fe/Au nanocrystals) has been presented. The technique may be useful for development of new highly efficient biosensors. Definitely an impressive piece of work.
Sourabh kaushal
commented on 28 December, 2012
very nice protocol:)i really like the stuff.
Ankit Singh
commented on 28 December, 2012
I think this is a pretty elegant protocol. The whole idea of combining the advantages of both reduced Graphene Oxide and Carbon Nanotube nanohybrid to achieve an enhanced synergistic effect for electroanalytical performance is pretty exciting. Since enhanced sensitivity is a major issue as mentioned, the whole process gives a very elegant way of utilizing the nanometer sized magnetic particles of iron, coated with another inert layer for enhanced biosensing. Regards!
aakash sinha
commented on 01 January, 2013
Congratulations to the Authors for this game changing innovation, I encourage you to bring this to the market , it seems to have huge potential for low cost diagnostics
gunmala sur
commented on 08 December, 2012
The protocol looks very exciting for sensitive detection of analytes, and could be an alternate for existing techniques
gunmala sur
commented on 08 December, 2012
thanks
gunmala sur
commented on 09 December, 2012
Very exciting protocol for sensitive detection of analytes. I need more details on the electrode characterization part of this method.
suresh aryan
commented on 28 December, 2012
A simple, efficient and innovative approach for biosensing, using new generation smart nanoscale materials (graphene, CNTs and Fe/Au nanocrystals) has been presented. The technique may be useful for development of new highly efficient biosensors. Definitely an impressive piece of work.
suresh aryan
commented on 28 December, 2012
A simple, efficient and innovative approach for biosensing, using new generation smart nanoscale materials (graphene, CNTs and Fe/Au nanocrystals) has been presented. The technique may be useful for development of new highly efficient biosensors. Definitely an impressive piece of work.
Sourabh kaushal
commented on 28 December, 2012
very nice protocol:)i really like the stuff.
Ankit Singh
commented on 28 December, 2012
I think this is a pretty elegant protocol. The whole idea of combining the advantages of both reduced Graphene Oxide and Carbon Nanotube nanohybrid to achieve an enhanced synergistic effect for electroanalytical performance is pretty exciting. Since enhanced sensitivity is a major issue as mentioned, the whole process gives a very elegant way of utilizing the nanometer sized magnetic particles of iron, coated with another inert layer for enhanced biosensing. Regards!
aakash sinha
commented on 01 January, 2013
Congratulations to the Authors for this game changing innovation, I encourage you to bring this to the market , it seems to have huge potential for low cost diagnostics
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Associated Publications
Enhancing electrochemical detection on graphene oxide-CNT nanostructured electrodes using magneto-nanobioprobes
by Priyanka Sharma, Vijayender Bhalla, Vinayak Dravid, +4
Scientific Reports (06 December, 2012)
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This is a preprint. It has not completed peer review.
Method Article
Enhancing graphene/CNT based electrochemical detection using magneto-nanobioprobes
C. Raman Suri
IMTECH
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 06 Dec, 2012
Community comments: 16
Metrics
Comments: 16
HTML Views: ...
License:
This work is licensed under a CC BY-NC 3.0 License. Read Full License
This protocol describes an optimized signal amplification strategy to develop an ultra-sensitive magneto-electrochemical biosensing platform. The new protocol combines the advantages of carbon nanotube (CNT) and reduced graphene oxide (rGO) together with electrochemical bursting of magnetic nanoparticles. The method involves synthesis of gold-iron (Au/Fe) nano-structures functionalized with specific antibodies to be used as nanobioprobes (Ab-Au/Fe). The next step requires the precise designing of the rGO/CNT nanohybrid sensing platform. The combined system offers the enhanced electrochemical properties giving a synergistic effect in electroanalytical performance of the resulting electrode material along with a large number of metal ions (Fe2+) available on electrode demonstrating ultra-high sensitivity of developed assay. This method provides a promising biosensing platform for environmental or clinical applications where sensitivity is a major issue
Figure 1
Figure 2
Figure 3
Figure 4
gunmala sur
commented on 08 December, 2012
The protocol looks very exciting for sensitive detection of analytes, and could be an alternate for existing techniques
gunmala sur
commented on 08 December, 2012
thanks
gunmala sur
commented on 09 December, 2012
Very exciting protocol for sensitive detection of analytes. I need more details on the electrode characterization part of this method.
suresh aryan
commented on 28 December, 2012
A simple, efficient and innovative approach for biosensing, using new generation smart nanoscale materials (graphene, CNTs and Fe/Au nanocrystals) has been presented. The technique may be useful for development of new highly efficient biosensors. Definitely an impressive piece of work.
suresh aryan
commented on 28 December, 2012
A simple, efficient and innovative approach for biosensing, using new generation smart nanoscale materials (graphene, CNTs and Fe/Au nanocrystals) has been presented. The technique may be useful for development of new highly efficient biosensors. Definitely an impressive piece of work.
Sourabh kaushal
commented on 28 December, 2012
very nice protocol:)i really like the stuff.
Ankit Singh
commented on 28 December, 2012
I think this is a pretty elegant protocol. The whole idea of combining the advantages of both reduced Graphene Oxide and Carbon Nanotube nanohybrid to achieve an enhanced synergistic effect for electroanalytical performance is pretty exciting. Since enhanced sensitivity is a major issue as mentioned, the whole process gives a very elegant way of utilizing the nanometer sized magnetic particles of iron, coated with another inert layer for enhanced biosensing. Regards!
aakash sinha
commented on 01 January, 2013
Congratulations to the Authors for this game changing innovation, I encourage you to bring this to the market , it seems to have huge potential for low cost diagnostics
gunmala sur
commented on 08 December, 2012
The protocol looks very exciting for sensitive detection of analytes, and could be an alternate for existing techniques
gunmala sur
commented on 08 December, 2012
thanks
gunmala sur
commented on 09 December, 2012
Very exciting protocol for sensitive detection of analytes. I need more details on the electrode characterization part of this method.
suresh aryan
commented on 28 December, 2012
A simple, efficient and innovative approach for biosensing, using new generation smart nanoscale materials (graphene, CNTs and Fe/Au nanocrystals) has been presented. The technique may be useful for development of new highly efficient biosensors. Definitely an impressive piece of work.
suresh aryan
commented on 28 December, 2012
A simple, efficient and innovative approach for biosensing, using new generation smart nanoscale materials (graphene, CNTs and Fe/Au nanocrystals) has been presented. The technique may be useful for development of new highly efficient biosensors. Definitely an impressive piece of work.
Sourabh kaushal
commented on 28 December, 2012
very nice protocol:)i really like the stuff.
Ankit Singh
commented on 28 December, 2012
I think this is a pretty elegant protocol. The whole idea of combining the advantages of both reduced Graphene Oxide and Carbon Nanotube nanohybrid to achieve an enhanced synergistic effect for electroanalytical performance is pretty exciting. Since enhanced sensitivity is a major issue as mentioned, the whole process gives a very elegant way of utilizing the nanometer sized magnetic particles of iron, coated with another inert layer for enhanced biosensing. Regards!
aakash sinha
commented on 01 January, 2013
Congratulations to the Authors for this game changing innovation, I encourage you to bring this to the market , it seems to have huge potential for low cost diagnostics
Associated Publications
Enhancing electrochemical detection on graphene oxide-CNT nanostructured electrodes using magneto-nanobioprobes
by Priyanka Sharma, Vijayender Bhalla, Vinayak Dravid, +4
Scientific Reports (06 December, 2012)