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Method Article
C. Raman Suri
IMTECH
Corresponding Author
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This work is licensed under a CC BY-NC 3.0 License. Read Full License
This protocol describes an optimized signal amplification strategy to develop an ultra-sensitive magneto-electrochemical biosensing platform. The new protocol combines the advantages of carbon nanotube (CNT) and reduced graphene oxide (rGO) together with electrochemical bursting of magnetic nanoparticles. The method involves synthesis of gold-iron (Au/Fe) nano-structures functionalized with specific antibodies to be used as nanobioprobes (Ab-Au/Fe). The next step requires the precise designing of the rGO/CNT nanohybrid sensing platform. The combined system offers the enhanced electrochemical properties giving a synergistic effect in electroanalytical performance of the resulting electrode material along with a large number of metal ions (Fe2+) available on electrode demonstrating ultra-high sensitivity of developed assay. This method provides a promising biosensing platform for environmental or clinical applications where sensitivity is a major issue
Keywords
Nanocomposites, nanobioprobes, metal ions, diuron
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Authors declare no competing financial interests.
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Associated Publications
Enhancing electrochemical detection on graphene oxide-CNT nanostructured electrodes using magneto-nanobioprobes
by Priyanka Sharma, Vijayender Bhalla, Vinayak Dravid, +4
Scientific Reports (06 December, 2012)
An open repository of community-contributed protocols sponsored by Nature Research.
Learn more about Protocol Exchange
Method Article
C. Raman Suri
IMTECH
Corresponding Author
Version History
CURRENT STATUS: Posted
Version 1
Posted 06 Dec, 2012
Community comments: 16
Metrics
Comments: 0
HTML Views: ...
License:
This work is licensed under a CC BY-NC 3.0 License. Read Full License
This protocol describes an optimized signal amplification strategy to develop an ultra-sensitive magneto-electrochemical biosensing platform. The new protocol combines the advantages of carbon nanotube (CNT) and reduced graphene oxide (rGO) together with electrochemical bursting of magnetic nanoparticles. The method involves synthesis of gold-iron (Au/Fe) nano-structures functionalized with specific antibodies to be used as nanobioprobes (Ab-Au/Fe). The next step requires the precise designing of the rGO/CNT nanohybrid sensing platform. The combined system offers the enhanced electrochemical properties giving a synergistic effect in electroanalytical performance of the resulting electrode material along with a large number of metal ions (Fe2+) available on electrode demonstrating ultra-high sensitivity of developed assay. This method provides a promising biosensing platform for environmental or clinical applications where sensitivity is a major issue
Figure 1
Figure 2
Figure 3
Figure 4
Authors declare no competing financial interests.
This is a list of supplementary files associated with this preprint. Click to download.
- supplement0.doc
Supplementary document Supplementary document
Loading...
Associated Publications
Enhancing electrochemical detection on graphene oxide-CNT nanostructured electrodes using magneto-nanobioprobes
by Priyanka Sharma, Vijayender Bhalla, Vinayak Dravid, +4
Scientific Reports (06 December, 2012)