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Method Article
Nadja C. Bigall
Fachbereich Physik, Philipps-Universtität Marburg, Renthof 7, 35037 Marburg, Germany and Philipps-Universtität Marburg,Technological Platform "Semiconductor Nanocrystals"
Corresponding Author
Wolfgang J. Parak
Fachbereich Physik, Philipps-Universtität Marburg, Renthof 7, 35037 Marburg, Germany and Philipps-Universtität Marburg,Technological Platform "Semiconductor Nanocrystals"
Corresponding Author
License:
This work is licensed under a CC BY-NC 3.0 License. Read Full License
In this protocol, a facile procedure for the transfer of quantum dots or different nanoparticles from organic synthesis into aqueous solution is described. Therefore, in the first step, poly(isobutylene maleic anhydride) is modified with hydrophobic side chains via amide bond formation. In the second step, this polymer is mixed with the nanoparticles and wrapped around them. The idea is let the side chains of the polymer intercalate with the inorganic ligands of the nanoparticles, and that the backbone of the polymer which is multifold charges due to the carboxylic groups leads to excellent water solubility. The nanoparticles are finally soluble in buffer solution and cleaned by gel electrophoresis or size exclusion chromatography. Additional functionalization of these nanoobjects is possible via amide bond formation.
Keywords
water transfer, nanoparticles, polymer coating
The authors declare no competing financial interests
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Version History
CURRENT STATUS: Posted
Version 1
Posted 28 Aug, 2012
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Associated Publications
Design of an Amphiphilic Polymer for Nanoparticle Coating and Functionalization
by Cheng-An J. Lin, Ralph A. Sperling, Jimmy K. Li, +5
Small (28 August, 2012)
Method Article
Nadja C. Bigall
Fachbereich Physik, Philipps-Universtität Marburg, Renthof 7, 35037 Marburg, Germany and Philipps-Universtität Marburg,Technological Platform "Semiconductor Nanocrystals"
Corresponding Author
Wolfgang J. Parak
Fachbereich Physik, Philipps-Universtität Marburg, Renthof 7, 35037 Marburg, Germany and Philipps-Universtität Marburg,Technological Platform "Semiconductor Nanocrystals"
Corresponding Author
Version History
CURRENT STATUS: Posted
Version 1
Posted 28 Aug, 2012
No community comments so far
Metrics
Comments: 0
HTML Views: ...
Subject Areas
Nanoscience and technology
License:
This work is licensed under a CC BY-NC 3.0 License. Read Full License
In this protocol, a facile procedure for the transfer of quantum dots or different nanoparticles from organic synthesis into aqueous solution is described. Therefore, in the first step, poly(isobutylene maleic anhydride) is modified with hydrophobic side chains via amide bond formation. In the second step, this polymer is mixed with the nanoparticles and wrapped around them. The idea is let the side chains of the polymer intercalate with the inorganic ligands of the nanoparticles, and that the backbone of the polymer which is multifold charges due to the carboxylic groups leads to excellent water solubility. The nanoparticles are finally soluble in buffer solution and cleaned by gel electrophoresis or size exclusion chromatography. Additional functionalization of these nanoobjects is possible via amide bond formation.
Loading...
Associated Publications
Design of an Amphiphilic Polymer for Nanoparticle Coating and Functionalization
by Cheng-An J. Lin, Ralph A. Sperling, Jimmy K. Li, +5
Small (28 August, 2012)