Identification of Molecular Subtypes in Pancreatic Adenocarcinoma with Predictive and Prognostic Importance
In this protocol, we describe methodologies used in the Nature Medicine manuscript “Subtypes of Pancreatic Ductal Adenocarcinoma and their Differing Response to Therapy”. Herein, we describe the computational pipeline used to identify subtypes of pancreatic ductal adenocarcinoma and their associated gene signature using integrated analysis of various gene expression profiles with clinical outcome.
This is a list of supplementary files associated with this preprint. Click to download.
ScreenExpression.r To screen variable and unique genes This R code can be used to screen for those genes with standard deviation greater than certain cutoff. In addition, in cases where multiple probes are available for a single gene, it selects only one probe with highest standard deviation for that gene.
Posted 04 Apr, 2011
Identification of Molecular Subtypes in Pancreatic Adenocarcinoma with Predictive and Prognostic Importance
Posted 04 Apr, 2011
In this protocol, we describe methodologies used in the Nature Medicine manuscript “Subtypes of Pancreatic Ductal Adenocarcinoma and their Differing Response to Therapy”. Herein, we describe the computational pipeline used to identify subtypes of pancreatic ductal adenocarcinoma and their associated gene signature using integrated analysis of various gene expression profiles with clinical outcome.
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