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Method Article
Identification of Molecular Subtypes in Pancreatic Adenocarcinoma with Predictive and Prognostic Importance
Joe Gray
Oregon Health and Science University
Corresponding Author
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This work is licensed under a CC BY-NC 3.0 License. Read Full License
In this protocol, we describe methodologies used in the Nature Medicine manuscript “Subtypes of Pancreatic Ductal Adenocarcinoma and their Differing Response to Therapy”. Herein, we describe the computational pipeline used to identify subtypes of pancreatic ductal adenocarcinoma and their associated gene signature using integrated analysis of various gene expression profiles with clinical outcome.
Keywords
cancer subtypes, pancreatic cancer, NMF, DWD
This is a list of supplementary files associated with this preprint. Click to download.
- supplement0.r
ScreenExpression.r To screen variable and unique genes This R code can be used to screen for those genes with standard deviation greater than certain cutoff. In addition, in cases where multiple probes are available for a single gene, it selects only one probe with highest standard deviation for that gene.
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Associated Publications
Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy
by Eric A Collisson, Anguraj Sadanandam, Peter Olson, +13
Nature Medicine (17 March, 2011)
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This is a preprint. It has not completed peer review.
Method Article
Identification of Molecular Subtypes in Pancreatic Adenocarcinoma with Predictive and Prognostic Importance
Joe Gray
Oregon Health and Science University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 04 Apr, 2011
No community comments so far
Metrics
Comments: 0
HTML Views: ...
License:
This work is licensed under a CC BY-NC 3.0 License. Read Full License
In this protocol, we describe methodologies used in the Nature Medicine manuscript “Subtypes of Pancreatic Ductal Adenocarcinoma and their Differing Response to Therapy”. Herein, we describe the computational pipeline used to identify subtypes of pancreatic ductal adenocarcinoma and their associated gene signature using integrated analysis of various gene expression profiles with clinical outcome.
Associated Publications
Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy
by Eric A Collisson, Anguraj Sadanandam, Peter Olson, +13
Nature Medicine (17 March, 2011)