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Method Article
Enantioseparation of racemic compounds in capillary electrophoresis using cationic single isomer cyclodextrin
Siu-choon Ng
Tan and Ng's Lab
Corresponding Author
Timothy T.Y. Tan
Tan and Ng's Lab
Corresponding Author
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Capillary electrophoresis (CE) is a relatively new separation technique that provides rapid analysis with high efficiency and resolution due to the use of electric field and a variety of selective modes. Cyclodextrins are the most commonly utilized chiral selectors added into the background electrolyte to perform enantioseparation. This protocol describes an example of CE enantioseparation using a recently reported chiral selector mono-6-deoxy-6-(3R,4R-dihydroxypyrrolidine)-β-CD chloride (dhypy-CDCl).
Keywords
Cyclodextrin, cationic, single isomer, enantioseparation, capillary electrophoresis, chiral.
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Associated Publications
Synthesis of cationic single-isomer cyclodextrins for the chiral separation of amino acids and anionic pharmaceuticals
by Weihua Tang and Siu-Choon Ng
Nature Protocols (21 February, 2011)
Chiral capillary electrophoresis with cationic pyrrolidinium-β-cyclodextrin derivatives as chiral selectors
by Yin Xiao, Yong Wang, Teng-Teng Ong, +5
Journal Of Separation Science (21 February, 2011)
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This is a preprint. It has not completed peer review.
Method Article
Enantioseparation of racemic compounds in capillary electrophoresis using cationic single isomer cyclodextrin
Siu-choon Ng
Tan and Ng's Lab
Corresponding Author
Timothy T.Y. Tan
Tan and Ng's Lab
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 22 Feb, 2011
No community comments so far
Metrics
Comments: 0
HTML Views: ...
Subject Areas
Biological techniques
License:
This work is licensed under a CC BY-NC 3.0 License. Read Full License
Capillary electrophoresis (CE) is a relatively new separation technique that provides rapid analysis with high efficiency and resolution due to the use of electric field and a variety of selective modes. Cyclodextrins are the most commonly utilized chiral selectors added into the background electrolyte to perform enantioseparation. This protocol describes an example of CE enantioseparation using a recently reported chiral selector mono-6-deoxy-6-(3R,4R-dihydroxypyrrolidine)-β-CD chloride (dhypy-CDCl).
Figure 1
Figure 2
Associated Publications
Synthesis of cationic single-isomer cyclodextrins for the chiral separation of amino acids and anionic pharmaceuticals
by Weihua Tang and Siu-Choon Ng
Nature Protocols (21 February, 2011)
Chiral capillary electrophoresis with cationic pyrrolidinium-β-cyclodextrin derivatives as chiral selectors
by Yin Xiao, Yong Wang, Teng-Teng Ong, +5
Journal Of Separation Science (21 February, 2011)