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Method Article
Siu-choon Ng
Tan and Ng's Lab
Corresponding Author
Timothy T.Y. Tan
Tan and Ng's Lab
Corresponding Author
License:
This work is licensed under a CC BY-NC 3.0 License. Read Full License
Capillary electrophoresis (CE) is a relatively new separation technique that provides rapid analysis with high efficiency and resolution due to the use of electric field and a variety of selective modes. Cyclodextrins are the most commonly utilized chiral selectors added into the background electrolyte to perform enantioseparation. This protocol describes an example of CE enantioseparation using a recently reported chiral selector mono-6-deoxy-6-(3R,4R-dihydroxypyrrolidine)-β-CD chloride (dhypy-CDCl).
Keywords
Cyclodextrin, cationic, single isomer, enantioseparation, capillary electrophoresis, chiral.
Figure 1
Figure 2
The authors declare no competing financial interests.
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Subject Areas
Biological techniques
Associated Publications
Synthesis of cationic single-isomer cyclodextrins for the chiral separation of amino acids and anionic pharmaceuticals
by Weihua Tang and Siu-Choon Ng
Nature Protocols (21 February, 2011)
Chiral capillary electrophoresis with cationic pyrrolidinium-β-cyclodextrin derivatives as chiral selectors
by Yin Xiao, Yong Wang, Teng-Teng Ong, +5
Journal Of Separation Science (21 February, 2011)
Method Article
Siu-choon Ng
Tan and Ng's Lab
Corresponding Author
Timothy T.Y. Tan
Tan and Ng's Lab
Corresponding Author
Version History
CURRENT STATUS: Posted
Version 1
Posted 22 Feb, 2011
No community comments so far
Metrics
Comments: 0
HTML Views: ...
Subject Areas
Biological techniques
License:
This work is licensed under a CC BY-NC 3.0 License. Read Full License
Capillary electrophoresis (CE) is a relatively new separation technique that provides rapid analysis with high efficiency and resolution due to the use of electric field and a variety of selective modes. Cyclodextrins are the most commonly utilized chiral selectors added into the background electrolyte to perform enantioseparation. This protocol describes an example of CE enantioseparation using a recently reported chiral selector mono-6-deoxy-6-(3R,4R-dihydroxypyrrolidine)-β-CD chloride (dhypy-CDCl).
Figure 1
Figure 2
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Associated Publications
Synthesis of cationic single-isomer cyclodextrins for the chiral separation of amino acids and anionic pharmaceuticals
by Weihua Tang and Siu-Choon Ng
Nature Protocols (21 February, 2011)
Chiral capillary electrophoresis with cationic pyrrolidinium-β-cyclodextrin derivatives as chiral selectors
by Yin Xiao, Yong Wang, Teng-Teng Ong, +5
Journal Of Separation Science (21 February, 2011)